Welcome to the 3C Patch Experience

At Reapplix, we have established that one of the keys to successful wound treatment lies in the body’s capacity to heal – and each patient is central to that process.

Every Wound Is Personal

Experience 3C Patch Wound Management – The novel 3-layer leukocyte, platelets, and fibrin patch that draws on each patient’s unique ability to help their healing process

 Using just a small sample of the patient’s blood – nothing else – the 3C Patch® System separates, coagulates and compacts the blood components into a solid patch.
Clinically Proven
Clinically Proven

 Clinical evidence from a large (n=269) international randomized controlled trial published in the Lancet (2018) confirms 3C Patch has a strong clinical efficacy on chronic diabetic foot ulcers compared to standard of care.1

Nationally covered
Nationally Covered
Clinically Proven

 Effective April 13, 2021, Medicare covers the 3C Patch for the treatment of chronic non-healing diabetic wounds for
20 weeks.2

A promise backed with evidence. Proven results including a large RCT published in The Lancet Diabetes & Endocrinology1 and supported with additional solid scientific and clinical data.
IWGDF Recommended
IWGDF Recommended

 The International Working Group of the Diabetic Foot recommends the use of 3C Patch - an autologous multilayer leukocyte, platelet, and fibrin patch as adjunctive treatment in diabetic foot ulcers that are difficult to heal3

Discover how 3C Patch is created and applied to a wound

Make a
3C Patch

Joins us for 2023 educational and industry events

Contact A Rep
SAWC Spring 2023
Next Live Event

May 14-18, 2024

Orlando, FL

The Symposium on Advanced Wound Care (SAWC) Spring | Wound Healing Society (WHS) taking place May 14-18, 2024 in Orlando, FL, is the leading meeting dedicated to the management, treatment, and prevention of wounds. The expert line-up of faculty, depth of discussions, and exposure to evidence-based practices and techniques are unparalleled. You'll receive invaluable wound care education that you can apply to practice to improve the lives of your patients. Register Now

See All Events

Start the process

15-20 MINUTES – the approximate time it takes to produce a 3C Patch®

The 3C Patch® Kit is a procedure pack providing the single-use components needed for the production of the 3C Patch®
Each 3C Patch® Kit is packed in an individual box and contains all the components needed to produce a 3C Patch®.
Each 3C Patch® Kit is packed in an individual box and contains all the components needed to produce a 3C Patch®.
The proprietary high speed centrifugation step separates cells and is a unique part of the patented 3C Patch® Process
Fibrin polymerizes during the coagulation step monitored by the centrifuge’s built-in optical sensor
Compaction forms the robust 3C Patch®
The unique process provides autologous wound management at the point of care, meaning a 100% unique patch prepared from the patient’s own blood. This fully automated process takes approximately 20 minutes:
Back to Top
The proprietary high speed centrifugation step separates cells and is a unique part of the patented 3C Patch® Process


18ml of blood is collected into the 3C Patch® device by vacuum. The device is placed into the centrifuge to generate a 3C Patch®.

The blood cells are separated into three layers using a proprietary process controlled by the centrifuge.

The important components of blood reaching a wound are; immune cells, platelets and growth factors. These components help orchestrate the wound healing response.

The filter is released to compact the leukocytes, platelets and fibrin creating the 3-layer patch.

In wound healing medical literature, it is acknowledged that leukocytes orchestrate healing and fight infection.32 This layer is to be placed directly in contact with the wound.
In wound healing medical literature it is acknowledged that platelets provide growth factors that are needed to grow blood vessels and form new granulation tissue.
Polymerized fibrin forms during the coagulation step and provides moisture retention and structural integrity for the 3C Patch®.
Back to Top

Transfer to the patient

Histological stain highlighting the three layers of the 3C Patch®

Histological image highlighting the three layers of the 3C Patch.

More than 800 different growth factors, cytokines and proteins have been detected in the 3C Patch® by multiplex analysis

Open the device and remove the 3C Patch®.


Place the 3C Patch® filter side up on a sterile absorbing surface.

Apply the filter side (checkered side) of the patch directly to the wound surface. The 3C Patch® may overlap intact skin.

Patients should avoid getting the 3C Patch® wet and be instructed not to change the dressing in direct contact with the patch and holding the patch in place.

Cover the 3C Patch® with the supplied primary dressing. Apply a secondary absorbent dressing (free choice, depending on the amount of exudate).

Back to Top

The Healing process

The use of 3C Patch® usually continues while wound closure is taking place. The timing depends on the specific wound aetiology. See Clinical Data section for a more detailed indication of when wound closure occurs.
Wound types: Wagner 1,2,3 ABI down to .5
1st Patch Application: Clean and debride the patient's 
wound to allow the cells
 and signaling molecules in 
3C Patch to interact with 
living tissue.
2nd and 3rd application: After the 2-3rd application
an increase in granulation
tissue is usually seen.
Back to Top

TAp To launch A Video

Clinical Evidence

The efficacy and regenerative capability of 3C Patch® is supported by solid clinical results, including a large scale randomized controlled trial (RCT) published in the highly recognized medical journal The Lancet Diabetes & Endocrinology in 2018. 

Review our case studies
  • 3C Patch Study Design
  • 3C Patch Intervention
  • 3C Patch Patients

Clinic Workflow

The fully automated and integrated centrifugation process offers seamless integration of 3C Patch Wound Management System into the clinic workflow.

Learn more about clinical workflow
  • 18ml blood collection by vacuum 

  • 3C Patch® Technology generates a 3C Patch® in a table top centrifuge 

  • Open the device and transfer the 3C Patch® to the wound 


Effective April 13, 2021, Medicare covers the 3C Patch® for the treatment of chronic non-healing diabetic wounds for 20 weeks.

Learn more about reimbursement
  • HCPCS Code information for 3C Patch, Reapplix


1.      Game F., Jeffcoate W., Tarnow L., Jacobsen JL., Whitham DJ., Harrison EF., Ellender SJ., Fitzsimmons D., LöndahlM., LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked randomized controlled trial. Lancet Diabetes Endocrinology. 2018; 6(11): 870-878.
2.      https://www.cms.gov/Medicare/Coverage/Coverage-with-Evidence-Development/Autologous-Platelet-rich-Plasma, NCT02224742
3.      Rayman G., Vas P., Dhatariya K., Driver V., Hartemann A., Londahl M., Piaggesi A., Apelqvist J., Attinger C.,Game F., on behalf of the International Working Group of the Diabetic Foot (IWGDF), IWGDF Guideline on interventions to enhance healing of foot ulcers in persons with diabetes, Part of the 2019 IWGDF Guidelines on the Prevention and Management of Diabetic Foot Disease.

Close Form
Thank you!
A 3C Patch representative will contact you shortly.
All fields marked with an * are required to complete the form.

Need assistance? Contact us at 3cpatch@reapplix.com